The fifth edition of Clinical Neurology, like its predecessors, offers a problem-oriented approach to neurology based on the authors' experience in teaching medical students and house staff at the University of California, San Francisco. Chapters are organized according to problems such as headache, seizures, stroke, and coma, because these are the conditions for which patients usually seek medical care. Careful history taking and neurologic examination are emphasized, as these remain the cornerstones of neurologic diagnosis, even in an era of technologic diagnostic advances.
The need to update this book arises from two main sources: rapid expansion of knowledge about the molecular basis of neurologic diseases and recent innovations in the treatment of disorders such as headache, epilepsy, stroke, Parkinson's disease, and multiple sclerosis. Accordingly, increased prominence has been given to molecular mechanisms of diseases—for example, Alzheimer's disease and the polyglutamine disorders, including Huntington's disease. Sections on treatment have been updated and expanded to reflect the introduction of new therapies for neurological disorders. The summary tables of therapeutic drugs and genetic disorders inside the front and back covers, which were introduced in the last edition, have been revised to maintain currency